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1H NMR Spectroscopic Survey of Plasma and Erythrocytes from Selected Marsupials and Domestic Animals of Australia

 

Nihal S. Agar1, Caroline D. Rae2, Bogdan E. Chapman2, and Philip W. Kuchel2


1Department of Physiology, University of New England, Armidale, N.S.W. 2351, Australia
2Department of Biochemistry, University of Sydney, Sydney, N.S.W. 2006, Australia (Tel: 02 692 2597)


ABSTRACT

1. 1H NMR spectra were acquired from whole plasma, intact erythrocytes, and ultrafiltrates of erythrocytes from nine native and eight introduced (domestic) Australian animals; single-pulse, spin-echo and 2-dimensional spectra were obtained. The aim was to detect and at least semi-quantify metabolites in the samples and compare the profiles amongst the species.

2. The Australian natives that were studied were all marsupials: greater brown bandicoot; bettong; eastern grey kangaroo; red kangaroo; koala; possum; red necked pademelon; Tammar wallaby; and wombat. The introduced mammals that were studied were: cat; cattle; dog; goat; horse; pig; rabbit; and sheep.

3. Because of the range of habitats and diets amongst the animals, it was postulated that the concentrations of the common metabolites in the blood would show marked differences and that there would also be some metabolites that were peculiar to a given animal. There were several major differences in the spectra: in the spectra of plasma, the glycoprotein and lipoprotein resonances showed the largest inter-species variation, whereas the most dramatic finding from the spectra of erythrocytes was a very high concentration of lysine in the cells from the Tammar wallaby.

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