Immunoproteomic Approach to Elucidating the Pathogenesis of Cryptococcosis Caused by Cryptococcus gattii
Sarah E. Jobbins,† Cameron J. Hill,‡ Jocelyn M. D’Souza-Basseal,§ Matthew P. Padula,‡ Ben R. Herbert,‡ and Mark B. Krockenberger*,†
The Faculty of Veterinary Science and the School of Molecular and Microbial Biosciences, the University of Sydney, and the Proteomics Technology Centre of Expertise, Faculty of Science, University of Technology Sydney, Australia
† Faculty of Veterinary Science.
‡ Proteomics Technology Centre of Expertise.
§ School of Molecular and Microbial Biosciences.
Cryptococcosis caused by Cryptococcus gattii is a devastating disease of immunocompetent hosts with an incompletely understood pathogenesis. Utilizing an immunoproteomic approach in a naturally occurring koala model of disease, a number of key proteins and pathways are identiﬁed in the early and late pathogenesis of cryptococcosis for the ﬁrst time. In particular, the thioredoxin system appears important in the pathogenesis of cryptococcosis caused by C. gattii VGII.