Koala Biovar of Chlamydia pneumoniae Infects Human and Koala Monocytes and Induces Increased Uptake of Lipids In Vitro
KATIE A. COLES,1,2* PETER TIMMS,3 AND DAVID W. SMITH2,4
Departments of Public Health1 and Microbiology,2 the University of Western Australia, and Western Australian Centre for Pathology and Medical Research, Sir Charles Gairdner Hospital,4 Perth, and Centre for Molecular Biotechnology, School of Life Sciences, Queensland University of Technology, Brisbane,3 Australia
We examined the ability of the koala biovar of Chlamydia pneumoniae to infect both Hep-2 cells and human monocytesandtheeffectofinfectionontheformationoffoamcells.Thekoalabiovarproducedlargeinclusions in both human and koala monocytes and in Hep-2 cells. Koala C. pneumoniae induced foam cell formation with and without added low-density lipoprotein, in contrast to TW183, which produced increased foam cell formation only in the presence of low-density lipoprotein.