logo

KOALA SCIENCE COMMUNITY
     Research, Connect, Protect

 

Search

Literature

Transspecies Transmission of the Endogenous Koala Retrovirus

Uwe Fiebig,1 Manuel Garcia Hartmann,2 Norbert Bannert,1 Reinhard Kurth,1 and Joachim Denner1* 

Robert Koch Institute, 13353 Berlin,1 

Zoo Duisburg, 47058 Duisburg,2 Germany

ABSTRACT

The koala retrovirus (KoRV) is a gammaretrovirus closely related to the gibbon ape leukemia virus and induces leukemias and immune deficiencies associated with opportunistic infections, such as chlamydiosis. HerewecharacterizeaKoRVnewlyisolatedfromananimalinaGermanzooandshowinfectionofhumanand rat cell lines in vitro and of rats in vivo, using immunological and PCR methods for virus detection. The KoRV transmembrane envelope protein (p15E) was cloned and expressed, and p15E-specific neutralizing antibodies able to prevent virus infection in vitro were developed. Finally, evidence for immunosuppressive properties of the KoRV was obtained.

 

  • All
  • 2013
  • Biogeography
  • Biology
  • Chlamydia
  • Diet
  • Disease
  • Ecology
  • Ellis
  • Eucalyptus
  • Genetics
  • Habitat
  • Infection
  • Interventions
  • Koala
  • Lunney
  • Threats
  • Timms
load more hold SHIFT key to load all load all